Bone-strengthening infusion for osteoporosis (zoledronic acid)
osteoporosis infusion · zoledronic acid · IV bone strengthening · bisphosphonate infusion
A medicine that strengthens the bones is given by drip into a vein. It is usually done once a year.
For osteoporosis, to lower the risk of fractures, when tablets are not suitable.
⏱ Duration: the drip usually takes 15 to 30 minutes, and the whole visit about an hour

Be sure to tell your doctor
How to prepare
- Tests. Before the infusion, your kidney function and calcium are usually checked.
- Water. Drink plenty of water before and after, unless your doctor limited it.
- Teeth. It is best to have your teeth treated beforehand. Tell your dentist you are getting this medicine.
- Vitamins. Take calcium and vitamin D as your doctor prescribed.
What to bring
- Your referral and test results
- Your ID
- A list of your medicines
How it goes
- The nurse checks your test results and how you feel
- A catheter is placed in a vein
- The drip is connected
- The medicine runs in for 15 to 30 minutes
- The catheter is removed and the spot is pressed
What you'll feel
- The drip itself usually does not hurt
- In the first 1 to 3 days there may be fever, aches and weakness, like a cold
- This reaction usually happens after the first infusion
Afterwards
- Drink water through the day
- For aches, you can take a fever reducer your doctor approved
- The next infusion is usually in a year. The doctor will tell you the date
Contact a doctor straight away if
- Severe jaw pain or a sore in the mouth that does not heal
- New pain in the thigh or groin
- Rash, swelling of the face, trouble breathing: call your local emergency number
Common questions
Why do I feel like I have the flu after the infusion?
This is a common reaction to the first dose. It usually passes in 1 to 3 days.
Do I need to tell my dentist?
Yes, always. Especially before a tooth is removed or implants are placed.