Metanephrines in blood and urine
metanephrines test · normetanephrine · catecholamines · pheochromocytoma test · 24-hour urine metanephrines
This blood or urine test checks substances made from stress hormones. It helps find rare tumors of the adrenal glands.
For attacks of high blood pressure with a racing heart, sweating, and headache, or when something was found in an adrenal gland.
⏱ Duration: the blood draw takes a few minutes, urine is collected for 24 hours; results usually come in a few days

Be sure to tell your doctor
How to prepare
- Medicines. Some medicines distort the result. Do not stop anything on your own. Your doctor will say if anything needs to be switched.
- Food and drinks. Usually for 24 hours: no coffee, strong tea, alcohol, or smoking. You are often asked to avoid bananas, nuts, and chocolate. Check with the lab.
- Blood. Blood is taken on an empty stomach. You usually lie down for about 20 to 30 minutes before the draw.
- 24-hour urine. Do not collect the first morning urine. Then for 24 hours, pee into a large container. The last portion is the next morning. Sometimes a preservative is added. The lab will give it to you.
What to bring
- Your referral or list of tests
- Your ID
- The 24-hour urine container or a sample poured from it, as the lab says
- The total urine volume for 24 hours, written down
How it goes
- For the blood test, you lie down quietly for about half an hour
- The nurse puts on a band and wipes the skin
- A quick prick, and blood fills the tube
- For the urine test, you bring all or part of the urine collected over 24 hours
- The lab worker writes down the volume and the collection time
What you'll feel
- A quick prick, like a pinch
- Collecting urine for 24 hours does not hurt, but you must not miss a single portion
Afterwards
- Press the cotton pad for 3 to 5 minutes
- After the test, you can eat and drink as usual
- The doctor will review the result. Sometimes the test is repeated
Contact a doctor straight away if
- The puncture site is very swollen, painful, and red
- An attack with very high blood pressure, a severe headache, or chest pain: call emergency services
Common questions
Can I drink coffee before the test?
Usually not. Caffeine can distort the result. The lab will tell you exactly how long to avoid it.
What if I missed one urine portion?
You will need to start the collection again. Otherwise the result will not be accurate.