Calcitonin and thyroglobulin
calcitonin test · thyroglobulin test · Tg · thyroid tumor markers
This blood test checks two substances made by the thyroid gland. They help the doctor watch thyroid nodules and check how you are after treatment.
Calcitonin is checked for thyroid nodules and for relatives if a rare type of thyroid cancer runs in the family. Thyroglobulin is checked after the thyroid has been removed.
⏱ Duration: the blood draw takes a few minutes; results usually come in 1 to 5 days

Be sure to tell your doctor
How to prepare
- Food. Blood is usually taken in the morning on an empty stomach: 8 to 12 hours without food. Plain water is fine. Check with the lab.
- The day before. For 24 hours: no alcohol and no hard workouts. Try not to smoke in the morning.
- Medicines. Do not stop anything on your own. Tell your doctor what you take. They will decide if anything needs to change before the test.
- Clothing. A sleeve you can easily roll up above the elbow.
What to bring
- Your referral or list of tests
- Your ID
- Past results of these tests. Comparing them matters
- Ultrasound reports and your hospital discharge summary after surgery, if you have them
How it goes
- You sit down and rest your arm on the armrest
- A band is tied above your elbow, and you are asked to clench your fist a few times
- The skin is wiped with antiseptic
- A quick prick. Blood fills the tubes in a few seconds
- The needle comes out, and a cotton pad is pressed on the spot
What you'll feel
- A quick prick, like a pinch
- Sometimes slight dizziness. Tell the nurse, and they will help you lie down
Afterwards
- Press the cotton pad for 3 to 5 minutes
- You can eat after the test
- Try to repeat the test at the same lab. That makes results easier to compare
Contact a doctor straight away if
- The puncture site is very swollen, painful, and red
Common questions
Why are thyroglobulin antibodies tested too?
These antibodies can get in the way of measuring thyroglobulin accurately. The doctor needs both results.
Does high calcitonin mean cancer?
Not always. It can be high for other reasons. The doctor will decide if more tests are needed.